Peptides for Weight Loss: Complete Guide and Facts

Can Peptide Therapy Help you Lose Fat?

by Saima
Peptides for Weight Loss

Obesity has become a major concern for many people around the globe. There are various remedies to get rid of this disorder, but the administration of bioactive peptides has recently become very useful.

Peptides are small sections of proteins accomplishing different tasks to ensure proper body functioning. With low molecular weight, easy nucleation, and good lipophilicity, peptides can help you lose weight. They’re chemically active compounds directly linked with the human body’s production of Human Growth Hormone (HGH), thus controlling obesity.

Let’s have a deep understanding of how peptides help to reduce weight. Keep reading!

What is meant by Peptide Therapy?

Peptide therapy refers to using peptides to get numerous amazing health benefits. They immensely affect the physiological and biochemical processes of human life. Protein powders, injectables, or capsules are the most common forms of peptides used to cure different disorders in the human body.

For instance, collagen peptide supplement powders emphasize the improvement of gut, skin, and hair health. Others can increase the levels of HGH to encourage an increase in energy.

They play important roles in the human body, such as:

  • Help reduce inflammation
  • Restore collagen
  • Rejuvenate, protect, and heal the skin cells
  • Can prevent bone damage by delaying aging signs
  • Improve hair growth and texture
  • Burn stubborn excessive fat
  • Increase muscle mass

How do Peptides Help in Weight Loss?

Our body can naturally synthesize peptide compounds through the transcription of DNA. They trigger the pituitary gland to synthesize and release more HGH in the bloodstream. Similarly, they also help induce the synthesis of insulin-like growth factor, which ultimately improves lean muscle mass and reduces fat.

The increased production of Human Growth Hormone due to peptides can assist you in your weight loss journey. HGH can boost the fat-burning capacity of cells by:

  • Up-regulating lipolytic pathways which help to burn excess abdominal fat
  • Increasing your skeletal or lean muscle mass, thus helping to strengthen muscles
  • Up-regulating stem cells and improving cellular autophagy

Advantages of Peptides to Burn Belly Fat

If you are wondering if the peptides are helpful in burning unwanted belly fat, the answer is yes. Some peptides promote fatty acid oxidation. They perform various lipolytic functions, i.e. the hydrolysis of triacylglycerols stored in adipose tissues.

Human growth hormone, together with its lipolytic fragment, can induce lysis or oxidation of fats in the body. Furthermore, research indicates that Natriuretic peptides (NPs) potently improve the mobilization of lipids, thus controlling their metabolic process thus helping reduce belly fat.

Expected Duration to Lose Weight with Peptide Therapy

Usually, peptides are injected directly into the bloodstream to enhance their absorption and efficacy. Your healthcare advisor prescribes a proper schedule and dosage depending on your health.

Initially, you may experience fat burning after a few weeks of peptide therapy. However, considerable weight loss (5-10% fat reduction) may take 3-6 months.

For optimal or long-lasting results, you should:

  • Take well-balanced diet
  • Do regular exercise
  • Reduce sugar and starch intake
  • A good sleep of about 6-8 hours a day

Also Read: How Lifting Weights Can Help You Lose Weight?

7 Wonderful Peptide for Weight Loss


Glucagon-like peptide-1 or GLP-1 is secreted by the endocrine cells of the ileum and is involved in insulin production in the body. Studies showcase that this peptide can help reduce hunger, thus causing body weight to drop. In human adipocytes, GLP-1 suppresses the gene expression linked with differentiation while promoting the expression of genes related to lipid degeneration


MOTS-C is a peptide derived from mitochondria and is involved in the activation of various cellular and systematic processes. Studies reveal the involvement of MOTS-C peptide in prompting lipid metabolism, decreasing fat gain, and improving glucose uptake during its breakdown. Moreover, data also supports that it is beneficial for weight loss and insulin sensitivity as it helps in bolster the formation of NAD+ and AMP-kinase.


Tesamorelin is an analogue of HGH which promotes the release of IGF-1 in humans and reduces adipose tissue accumulation. It fights various disease complications in humans, especially excess abdominal fat. Tesamorelin is found to be very helpful in eradicating visceral adiposity and reducing the levels of triglycerides in humans, thus contributing to the weight loss process.


Studies showcase that being a fragment of the C-terminus of human growth hormone, AOD9604 boosts the fat-burning ability of HGH without any side effects to the body. Administration of this peptide alongside exercise and a proper diet can help you lose weight faster. Data reveals that AOD9604 prompts fatty acid oxidation and lipolysis in the body.

CJC 1295

CJC 1295 acts act as a stimulator of HGH secretion in the body. Their main function is to improve protein levels and regulate muscle growth. It also helps your body release more HGH, promoting lean muscle mass formation and keeping a better lipid profile. CJC 1295 is also highly beneficial in replenishing skin by repairing damaged skin cells.


Ipamorelin increases the production of HGH in the body as it belongs to the class of peptides known as “Growth Hormone Secretagogues”. Using this peptide can help improve the weight loss process, better sleep, more energy, and long-term availability of HGH in the body. Patients taking this peptide therapy for 3 months reportedly show an elevation in metabolism, fat loss, and improvement in the body’s composition.


Growth Hormone-releasing Hexapeptide (GHRP-6) consists of about 28 amino acids. Studies explain how this secretagogue promotes the formation of growth hormone in the body, ultimately leading to increased body mass with a gradual fat reduction.

It prompts the level of both GH and insulin-like growth factors, therefore turning out to be a very useful product for athletes who wish to improve their workout stamina. Meanwhile, GHRP-6 promotes HGH response and evidence suggests that the Growth hormone helps users gain 8.8% body mass and a 14% decrease in fat mass.

Concluding Remarks

Losing weight is not easy, no matter which treatment option you use. Nowadays, peptides are being extensively used for weight loss and proved to be much more effective. However, being consistent and following the proper guidelines of your physician along with peptide therapy can significantly reduce weight.

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